Regulatory Toxicology and Pharmacology

The difference between hazard and risk. Ensuring the safety of fragrances is a priority for both consumers and industry.

European Regulatory Change

The European Commission restricts the use of cyclic silicones - A note from the ASCC Technical Committee

ASCC Position Statement – ‘Reef Safe’

ASCC POSITION STATEMENT – “REEF SAFE” Prepared by John Staton - ASCC Technical Committee August 2019 – Updated August 2022

4-MBC Banned in EU

Due to concerns about endocrine disruption, this material has, as of 1 May 2026, been banned in the EU and will be banned by the UK in January 2027. It is also currently under review by the TGA. READ MORE.

The difference between hazard and risk: the dose range prevalent in toxicological studies vs real life fragrance exposure

Kaushal Joshi: Research Institute for Fragrance Materials, Mahwah, NJ, United States of America
Arianna Bartlett: Research Institute for Fragrance Materials, Mahwah, NJ, United States of America
Wolfgang Dekant: University of Wuerzburg, Department of Toxicology, Würzburg, Germany
I. Glenn Sipes: University of Arizona, College of Medicine, Department of Pharmacology, Tucson, AZ, United States of America
Gerhard Eisenbrand: Food Chemistry & Toxicology, RPTU Kaiserslautern-Landau, Kühler Grund 48/1, Heidelberg, Germany

Regulatory Toxicology and Pharmacology

Regulatory Toxicology and Pharmacology

Table of Contents

European Regulatory Change

ASCC Position Statement – ‘Reef Safe’

4-MBC Banned in EU

The difference between hazard and risk: the dose range prevalent in toxicological studies vs real life fragrance exposure